Heart Rate Variability Analysis to Predict Onset of Ventricular Tachyarrhythmias in Implantable Cardioverter Defibrillators.

Abstract

Implantable cardioverter defibrillators (ICDs) are commonly used in patients at high risk of sudden cardiac death (SCD) to help prevent and treat life-threatening arrhythmia. Up to 80% of cases of sudden cardiac death are caused by ventricular tachyarrhythmias (VTA) and the accurate prediction of VTA in patients with ICDs can help prevent SCD. Early prediction allows tiered and less invasive therapies to be used to help prevent VTA which are more easily tolerated by the patient and are less battery intensive. In this work, a comparative study of three types of frequency domain features (spectral, bispectrum, and Fourier-Bessel) for VTA prediction is presented based on heart rate variability (HRV) signals between one and five minutes prior to known SCD. Using Fourier-Bessel features and a standard classification approach resulted in the best performance of 87.5% accuracy, 89.3% sensitivity and 85.7% specificity. These results suggest that Fourier-Bessel features are a promising approach for SCD prediction, and that new feature development can help improve both the sensitivity and specificity of SCD prediction in ICDs.