Abstract
Heart rate variability parameters and the level of convulsive readiness during pentylenetetrazole-induced kindling in rats were analyzed using telemetric ECG and EEG monitoring. Analysis of ECG recorded over many days showed that heart rate variability was equally reduced after 7 and 27 days of kindling irrespective of the level of convulsive readiness. Reduced sympathovagal index after 7 days of kindling showed the compensatory character of changes. However, compensatory mechanisms cannot prevent high risk of life-threatening arrhythmias. High convulsive readiness after 27 days of kindling was accompanied by a shift of autonomic balance towards the increase in sympathetic tone, which may lead to decompensation and transition to a prenosological state.
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