Heart Rate Fragmentation: A Symbolic Dynamical Approach.

Madalena D Costa,Ary L Goldberger,Roger B Davis

doi:10.3389/fphys.2017.00827

Madalena D Costa, Ary L Goldberger + Show 1 more

Open Access

https://doi.org/10.3389/fphys.2017.00827

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Abstract

Background: We recently introduced the concept of heart rate fragmentation along with a set of metrics for its quantification. The term was coined to refer to an increase in the percentage of changes in heart rate acceleration sign, a dynamical marker of a type of anomalous variability. The effort was motivated by the observation that fragmentation, which is consistent with the breakdown of the neuroautonomic-electrophysiologic control system of the sino-atrial node, could confound traditional short-term analysis of heart rate variability.Objective: The objectives of this study were to: (1) introduce a symbolic dynamical approach to the problem of quantifying heart rate fragmentation; (2) evaluate how the distribution of the different dynamical patterns (“words”) varied with the participants' age in a group of healthy subjects and patients with coronary artery disease (CAD); and (3) quantify the differences in the fragmentation patterns between the two sample populations.Methods: The symbolic dynamical method employed here was based on a ternary map of the increment NN interval time series and on the analysis of the relative frequency of symbolic sequences (words) with a pre-defined set of features. We analyzed annotated, open-access Holter databases of healthy subjects and patients with CAD, provided by the University of Rochester Telemetric and Holter ECG Warehouse (THEW).Results: The degree of fragmentation was significantly higher in older individuals than in their younger counterparts. However, the fragmentation patterns were different in the two sample populations. In healthy subjects, older age was significantly associated with a higher percentage of transitions from acceleration/deceleration to zero acceleration and vice versa (termed “soft” inflection points). In patients with CAD, older age was also significantly associated with higher percentages of frank reversals in heart rate acceleration (transitions from acceleration to deceleration and vice versa, termed “hard” inflection points). Compared to healthy subjects, patients with CAD had significantly higher percentages of soft and hard inflection points, an increased percentage of words with a high degree of fragmentation and a decreased percentage of words with a lower degree of fragmentation.Conclusion: The symbolic dynamical method employed here was useful to probe the newly recognized property of heart rate fragmentation. The findings from these cross-sectional studies confirm that CAD and older age are associated with higher levels of heart rate fragmentation. Furthermore, fragmentation with healthy aging appears to be phenotypically different from fragmentation in the context of CAD.

Highlights

Analysis of fluctuations in cardiac interbeat intervals, under the rubric of heart rate variability (HRV), continues to generate much interest as a uniquely accessible window into the complex network of regulatory mechanisms controlling the sino-atrial (SA) node (HRV, 1996; Billman, 2013)
Anomalous shortterm variability is important for two major reasons: (1) it may confound the assessment of vagal tone modulation using conventional time and frequency domain HRV measures, leading to inflated estimates of “healthy” autonomic function in the elderly and especially in those with clinical or pre-clinical organic heart disease; and (2) its presence, itself, may be a novel dynamical biomarker of pathology and increased risk of adverse cardiovascular outcomes
To gain additional insight into the temporal structure of heart rate fragmentation, we introduce a symbolic dynamical approach to the quantification of this property

Summary

Introduction

Analysis of fluctuations in cardiac interbeat intervals, under the rubric of heart rate variability (HRV), continues to generate much interest as a uniquely accessible window into the complex network of regulatory mechanisms controlling the sino-atrial (SA) node (HRV, 1996; Billman, 2013). Short-term fluctuations in heart rate are not always a marker of healthy cardiopulmonary interactions (Makikallio et al, 1999; Domitrovich and Stein, 2002; Stein, 2002; Wiklund et al, 2008; Costa et al, 2017) (Figure 1, first three rows). They may be associated with abnormalities in the function of the neuroautonomic system, the SA node and other electrophysiologic components (Geiger and Goerner, 1945; Binkley et al, 1995; Jalife, 2013). The effort was motivated by the observation that fragmentation, which is consistent with the breakdown of the neuroautonomic-electrophysiologic control system of the sino-atrial node, could confound traditional short-term analysis of heart rate variability

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