Abstract
Two strains of highly inbred mice were given classical conditioning with noise as CS and shock as US. Control groups for pseudoconditioning were included, and heart rate was measured before and after conditioning. Heart rate was elevated after conditioning (p<0.01) but without evidence of classical conditioning. The control procedure increased heart rate more than the classical procedure (p<0.02), indicating an anxious response, independent of the pseudoconditioned stimulus, which complicates use of this procedure as control in studying classical conditioning. The extent of the anxious response varied with strain (p=0.02). There was also a significant (p<0.01) main effect of strain on heart rate.
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