Heart rate and death and hospitalization for heart failure in patients with persistent or permanent atrial fibrillation: Insights from the ARISTOTLE trial

Dragos Vinereanu,Daniel M Wojdyla,John H Alexander,Renato D Lopes,Sana M Al-Khatib,Bernard J Gersh,M Cecilia Bahit,Stefan H Hohnloser,Greg C Flaker,Marten Rosenquist,Ziad Hijazi,Lars Wallentin,Christopher B Granger

doi:10.1016/j.ahj.2023.07.006

Heart rate and death and hospitalization for heart failure in patients with persistent or permanent atrial fibrillation: Insights from the ARISTOTLE trial

Dragos Vinereanu, Daniel M Wojdyla + Show 11 more

https://doi.org/10.1016/j.ahj.2023.07.006

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Journal: American Heart Journal

Publication Date: Jul 26, 2023

Affiliation: Uppsala University, Mayo Clinic, Goethe University Frankfurt, Karolinska Institutet, Clinical Research Institute, Duke University, University of Missouri

#Significant Increase In Death #Persistent Atrial Fibrillation + Show 8 more

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Abstract

Rate control is fundamental in the treatment of patients with atrial fibrillation (AF). The independent association of heart rate with outcomes and range of heart rate associated with best outcomes remains uncertain. We assessed the relationship between heart rate and clinical outcomes in patients with persistent or permanent AF enrolled in the randomized, double-blind ARISTOTLE trial. In patients with persistent or permanent AF, a faster heart rate is associated with a modest, but statistically significant increase in death and heart failure hospitalizations. Trial RegistrationClinicalTrials.gov (NCT00412984).

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