Abstract
Background: We aimed to explore the relationship between lifestyle factors, cancer family history, and gastric cancer risk.Methods: We examined the association between lifestyle factors, cancer family history, and gastric cancer risk based on a population-based case-control study in Taixing, China, with 870 cases and 1928 controls. A lifestyle score was constructed considering body shape, smoking, alcohol drinking, tooth brushing habit, and food storage method. Unconditional logistic regression models were used to calculate odd ratios (ORs) and 95% confidence intervals (CIs).Results: Compared with participants with a lifestyle score of 0, subjects with a lifestyle score of 1 (OR 0.59, 95%CI 0.43–0.83), 2 (OR 0.42, 95%CI 0.30–0.59), 3 (OR 0.29, 95%CI 0.20–0.41), 4 (OR 0.20, 95%CI 0.13–0.32), or 5 (OR 0.10, 95%CI 0.04–0.22) had a lower risk of gastric cancer (P for trend < 0.001). Overall, 34% of gastric cancer cases (95%CI 27–41%) can be attributed to non-compliance with ≥3 healthy lifestyle. Family history of early-onset cancer is closely related to the occurrence of gastric cancer, with an OR ranging from 1.77 to 3.27. Regardless of family history, a good lifestyle is associated with a reduced risk of gastric cancer, with an OR value between 0.38 and 0.70.Conclusions: The early-onset cancer family history is closely related to the occurrence of gastric cancer and a good lifestyle is associated with a reduced risk of gastric cancer regardless of family history. Our results provide a basis for identifying and providing behavior guidance of high-risk groups of gastric cancer.
Highlights
Gastric cancer (GC) was the fifth most common cancer in the world in 2020 [1], and more than 40% of new cases and deaths from GC occurred in China [2]
Based on the data collected in this project, we explored the relationship between combined lifestyle factors, family history of cancer, and GC risk, in order to provide bases for the prevention and control of GC
We further explored the relationship between food storage method and the risk of GC and found that storing food in airtight containers and low temperatures were associated with reduced GC risks, with odds ratios (ORs) of 0.53 (95%confidence intervals (CIs) 0.42–0.67) and 0.70 (95%CI 0.56–0.87), respectively (Supplementary Table S1)
Summary
Gastric cancer (GC) was the fifth most common cancer in the world in 2020 [1], and more than 40% of new cases and deaths from GC occurred in China [2]. The observed reduced GC risk associated with refrigerator usage suggests that food storage method may be one of the GC-risk-related lifestyle factors [19]. The reality that these lifestyle factors often appear together makes it important to explore their combined effects on GC risk. Among people with different types of family history of malignancy, exploring the relationship between combined lifestyle factors and GC risk will provide information to develop the behavioral guidance for GC high-risk groups. We aimed to explore the relationship between lifestyle factors, cancer family history, and gastric cancer risk
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
