Abstract
Despite many effort to identify and control the factors involved in polycystic ovary syndrome (PCOS), there are no available reports indicating the association of healthy eating index (HEI) and PCOS. The present study has been conducted to examine the relationship between HEI and PCOS. In this case-control study, the study population comprised 297 women aged 20-40 yr referred to Baqiyatallah Hospital Clinics, Tehran, Iran in two groups: case group (n=99) and control group (n=198). The usual dietary data were collected using a validated 168-item semi-quantitative food frequency questionnaire. Standard anthropometric measurements (height, weight, and waist circumference) were also taken. Unconditional logistic regression was used to analyze the relationship between the PCOS and the HEI. The mean age and body mass index of case and control groups were 29±5.5 vs. 29.5±6 yr and 26.6±4.8 vs. 26±4.2 kg/m², respectively (p=0.752, p=0.822). Mean HEI scores for the case and control groups were found to be 61 and 65, respectively. In final model and after adjustment for confounders, the prevalence of PCOS in subjects in the highest tertile HEI score was significantly (50%) less than those in the lowest tertile HEI score (OR=0.50; 95% CI: 0.25-0.74, p=0.001). Our results suggest that HEI score is inversely associated with the risk of PCOS in adult women.
Highlights
Polycystic ovary syndrome (PCOS) is one of the most common endocrinology disorders among women in reproductive age, which involves about 7.8-18.8% of the world’s women population, depending on the diagnostic criteria [1]
The mean healthy eating index (HEI) score and its components in the case and control groups are presented in table II
We observed that individuals in the highest compared to the lowest HEI scores had 50% lower risk of prevalent polycystic ovary syndrome (PCOS)
Summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrinology disorders among women in reproductive age, which involves about 7.8-18.8% of the world’s women population, depending on the diagnostic criteria [1]. This syndrome is characterized by heterogeneous symptoms, including the amenorrhea, irregular menstrual cycles, clinical or laboratory evidence of androgen excess, morphological changes, and the presence of antral follicle in the ovaries [2]. Lifestyle interventions have been recommended as first-line treatment in women with PCOs [8] Most of these interventions focus on changing the dietary pattern, physical activity, and weight loss [9, 10]. Conclusion: Our results suggest that HEI score is inversely associated with the risk of PCOS in adult women
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