Abstract
BackgroundNerve‐sparing (NS) surgery was developed to improve postoperative sexual and potentially urological outcomes after radical prostatectomy (RP). However, it is largely unknown how NSRP affects health‐related quality of life (HRQoL) including urinary and sexual outcomes in prostate cancer (PC) survivors 5‐10 years after diagnosis in comparison with Non‐NSRP.MethodsThe study population included 382 stage pT2‐T3N0M0 PC survivors 5‐10 years post diagnosis, who were identified from the multiregional Prostate Cancer Survivorship in Switzerland (PROCAS) study. Briefly, in 2017/2018, PC survivors were identified via six population‐based cancer registries based in both German‐ and French‐speaking Switzerland. HRQoL and PC‐specific symptom burden was assessed using the EORTC QLQ‐C30 and EORTC QLQ‐PR25 questionnaires. Differences in HRQoL outcomes between survivors treated with NSRP (uni‐ & bilateral) and Non‐NSRP were analyzed with multivariable linear regression adjusted for age, years since diagnosis, cancer stage, comorbidities at diagnosis, and further therapies, if appropriate. Multiple imputation was performed to minimize the bias due to missing data.ResultsFive to ten years after diagnosis, PC survivors treated with NSRP and Non‐NSRP reported similar symptom burden and comparable HRQoL function scores. The only significant differences were reported for sexual activity, whereas PC survivors who underwent NSRP reported statistically significant (P = .031) higher sexual activity than those on Non‐NSRP. NSRP and Non‐NSRP reported similar scores for urinary symptoms and all other HRQoL outcomes.ConclusionsOur results support nerve‐sparing techniques as an option to improve postoperative sexual, but not urinary outcomes after RP in long‐term PC survivors.
Highlights
Radical prostatectomy (RP) is the most common treatment strategy for men diagnosed with prostate cancer (PC) [1], the survival benefit for PC survivors treated with radical prostatectomy (RP) compared to other primary management options remains unclear [2,3,4]
For PC survivors treated with Non-NSRP mean time since diagnosis was 7.8 years, whereas it was 7.4 years for PC survivors treated with NSRP
Given the increasing numbers of long-term PC survivors [19], it is imperative to understand whether treatment modalities such as NSRP may result in long-lasting health benefits including better health-related quality of life (HRQoL) and lower PC-specific symptom burden
Summary
Radical prostatectomy (RP) is the most common treatment strategy for men diagnosed with prostate cancer (PC) [1], the survival benefit for PC survivors treated with RP compared to other primary management options remains unclear [2,3,4]. Nerve-sparing (NS) technique was developed to improve postoperative sexual function (SEF) [8] and potentially urinary outcomes after RP. Nerve-sparing (NS) surgery was developed to improve postoperative sexual and potentially urological outcomes after radical prostatectomy (RP). It is largely unknown how NSRP affects health-related quality of life (HRQoL) including urinary and sexual outcomes in prostate cancer (PC) survivors 5-10 years after diagnosis in comparison to Non-NSRP
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
