Abstract
BackgroundAlthough several studies have reported an association between tuberculosis and health-related quality of life, the change in health-related quality of life after pulmonary tuberculosis has been rarely studied. The purpose of this study was to investigate the effect of past history of pulmonary tuberculosis on health-related quality of life using a nationwide, cross-sectional, observational study in Korea.MethodsAmong 72,751 people selected using a stratified multi-stage sampling method, 7260 Korean participants were included using propensity score matching. Past history of pulmonary tuberculosis was defined as a previous diagnosis of pulmonary tuberculosis excluding patients with active pulmonary tuberculosis. The primary outcome, health-related quality of life, was assessed by EQ-5D disutility.ResultsBefore matching, the mean EQ-5D of individuals with pulmonary tuberculosis history was lower (0.066 vs. 0.056, p: 0.009). However, the difference was nullified after matching (0.066 vs. 0.062, p = 0.354). In multivariable Poisson regression analysis, EQ-5D disutility score was not associated with past pulmonary tuberculosis history. In subgroup analysis, past pulmonary tuberculosis history increased odds of low health-related quality of life in young (odds ratio [OR] 1.57, 95% confidence interval [CI] 1.17–2.11, p = 0.003), unmarried (OR 1.98, 95% CI 1.05–3.73, p = 0.036), or separated patients (OR 1.30, 95% CI 1.02–1.66, p = 0.032). Age and marital status were modulating factors on the effect of past pulmonary tuberculosis history on health-related quality of life.ConclusionsThere was no difference in health-related quality of life between individuals with and without past pulmonary tuberculosis history. Young and unmarried groups had increased odds for low health-related quality of life after pulmonary tuberculosis due to modulating effects of age and marital status.
Highlights
Several studies have reported an association between tuberculosis and health-related quality of life, the change in health-related quality of life after pulmonary tuberculosis has been rarely studied
For the 25,214 participants, 7260 matched participants were selected using propensity score matching with age, sex, body mass index (BMI), marital status, smoking status, education, regular exercise, F EV1, functional vital capacity (FVC), and F EV1/FVC
Individuals with past pulmonary TB history were younger with lower BMI compared with those without pulmonary TB history
Summary
Several studies have reported an association between tuberculosis and health-related quality of life, the change in health-related quality of life after pulmonary tuberculosis has been rarely studied. The incidence of pulmonary TB has decreased with vaccinations and the development of strategies for prevention and treatment, approximately 10 million people are infected with TB, and 1.5 million people died in 2019 worldwide [2]. Healthrelated quality of life (HRQoL) has been recently suggested as an additional treatment goal for many diseases, including pulmonary TB, a highly contagious disease that requires isolation and long-term treatment [6,7,8]. These factors can affect HRQoL as well as mental health issues such as depression and anxiety disorder [9, 10]. In the treatment of pulmonary TB, the HRQoL of the patient must be considered in addition to biological management
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