Abstract
The objective of our study was to describe the epidemiological profile of blood culture isolates in the neonatology - neonatal intensive care unit of the Mohammed VI University Hospital of Oujda (Morocco) and to specify the resistance profile of the main germs isolated to antibiotics .This is a retrospective and descriptive study of 21 months from December 14, 2016 to September 14, 2018 and covering all positive blood cultures processed in the microbiology laboratory in accordance with REMIC (reference in medical microbiology) and EUCAST (European Committee on Antimicrobial Susceptibility Testing).contaminated blood cultures were excluded. As results, we collected 275 positive blood cultures. They occurred in the context of intravascular device (IVD) use in 59% (n=162) of cases. The most isolated bacterial groups were coagulase-negative staphylococci (CNS) 41.45 %( n=114), followed by Enterobacteriaceae 32.36 %( n=89).CNS were resistant to all beta-lactams in 57.89 %( n=66), and to glycopeptides in 5.26 %( n=6). Enterobacteriaceae were producers of extended-spectrum betalactamases in 79.77% (n=71) and producers of carbapenemases in 13.48% (n=12) of cases. The alarming increase of enterobacteriaceae isolates and their antibiotic resistance rates should encourage the reinforcement of hygiene measures in our University Hospital.
Highlights
Incomplete inflammatory immune responses make newborns more susceptible to bacterial invasion of the bloodstream, and the risk is even higher in children born prematurely [ 1]With improved obstetrical management and the use of antibiotics, early neonatal sepsis is becoming less common
The objective of our study was to describe the epidemiological profile of blood culture isolates in the neonatology-neonatal intensive care unit of the
Mohammed VI University Hospital of Oujda (Morocco) and to specify the resistance profile of the main germs isolated to antibiotics
Summary
With improved obstetrical management and the use of antibiotics, early neonatal sepsis is becoming less common. It is one of the most frequent causes of neonatal morbidity and mortality in the preterm population. All newborns with suspected sepsis are evaluated promptly and started on antibiotic therapy before bacteriological confirmation. Identification of an organism and appropriate antibiotic treatment are essential to prevent increasing mortality and morbidity [3]. The objective of our study was to describe the epidemiological profile of blood culture isolates in the neonatology-neonatal intensive care unit of the Mohammed VI University Hospital of Oujda (Morocco) and to specify the resistance profile of the main germs isolated to antibiotics
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