Health Utility and Its Relationship with Disease Activity and Physical Disability of Patients with Psoriatic Arthritis in Thailand

Abstract

Abstract This study aimed to estimate health utility and related factors among Thai patients with psoriatic arthritis (PsA). A cross-sectional study was performed on patients with PsA. A structured face-to-face interview was conducted including baseline characteristics, EQ-5D-5L (Thai Version) for health utility, the Thai version of the Health Assessment Questionnaire Disability Index (Thai HAQ) for physical disability and Psoriasis Area and Severity Index (PASI) for the severity of skin lesions. Patients’ disease activity was measured by the clinical Disease Activity Index for Psoriatic Arthritis. A linear regression analysis was performed to relate health utility and its factors. Of 84 patients enrolled, 67 (79.8%) had remission or low disease activity. The mean ± SD overall health utility was 0.87 ± 0.15. The health utility score of patients with low disease activity was significantly greater than that of those with moderately active to active disease activity (0.89 ± 0.12 vs. 0.72 ± 0.19, P < 0.001). The HAQ-DI (β = -0.213, 95%CI; -0.263 to -0.164, P < 0.001) and PASI (β = -0.006, 95%CI; -0.049 to -0.003, P = 0.001) were found to be significantly related factors for health utility. In conclusion, Thai patients with PsA possessed high health utility. The HAQ-DI and PASI were strongly related to patients’ health utility. Keywords: Utility, Disability, HAQ-DI, EQ-5D-5L, Psoriatic arthritis, Health-related quality of life