Abstract
We aimed to measure health utilities in patients with diabetes mellitus (DM) in Taiwan and to estimate the impact of common DM-related complications and adverse effects (AEs) on health utilities. The present study was a cross-sectional survey of DM patients at a metropolitan hospital. Respondents’ health-related quality of life (HRQoL) was assessed by the EQ-5D-5L, and ordinary least-squares (OLS) regression was used to estimate the impact of self-reported DM-related complications and AEs on health utilities after controlling for age, gender, and duration of DM. A total of 506 eligible adults with type 2 DM (T2DM) were enrolled. The EQ-5D index values in our study sample ranged from −0.13 to 1, with a mean ± standard deviation of 0.88 ± 0.20. As indicated by the negative regression coefficients, the presence of any complication or AE was associated with lower EQ-5D index values, and the greatest impact on the score was made by amputation (−0.276), followed by stroke (−0.211), and blindness (−0.203). In conclusion, the present study elicited health utilities in patients with T2DM in Taiwan using the EQ-5D-5L. These estimated utility decrements provided essential data for future DM cost–utility analyses that are needed as a result of the increasing prevalence and health expenditures of DM.
Highlights
According to the 2016 Global Report on Diabetes published by the World Health Organization, there were 422 million adults with diabetes mellitus (DM) around the world in 2014, a quadruple increase since 1980, and the overall global DM prevalence had increased from 4.7% in 1980 to 8.5% in 2014 [1]
A review by Beaudet et al [8] summarized health utilities associated with DM-related complications and adverse effects (AEs) in studies that met the National Institute for Health and Care Excellence reference case criteria
Beaudet et al reported that the utility decrements associated with DM-related complications and AEs were: −0.014 for hypoglycemia, −0.055 for myocardial infarction (MI), −0.090 for ischemic heart disease (IHD), −0.108 for congestive heart failure (CHF), −0.164 for stroke, −0.164 for end-stage renal disease (ESRD), and −0.280 for amputation
Summary
According to the 2016 Global Report on Diabetes published by the World Health Organization, there were 422 million adults with diabetes mellitus (DM) around the world in 2014, a quadruple increase since 1980, and the overall global DM prevalence had increased from 4.7% in 1980 to 8.5% in 2014 [1]. A few studies have measured utility decrements to estimate the impact of DM-related complications on HRQoL. A review by Beaudet et al [8] summarized health utilities associated with DM-related complications and adverse effects (AEs) in studies that met the National Institute for Health and Care Excellence reference case criteria (i.e., studies that used the EQ-5D for the measurement of HRQoL). Beaudet et al reported that the utility decrements associated with DM-related complications and AEs were: −0.014 for hypoglycemia, −0.055 for myocardial infarction (MI), −0.090 for ischemic heart disease (IHD), −0.108 for congestive heart failure (CHF), −0.164 for stroke, −0.164 for end-stage renal disease (ESRD), and −0.280 for amputation
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
