Abstract
The purpose of this study was to assess health status (HS) in patients with clinical suspicion of obstructive sleep apnea (OSA) in order to estimate the dose response relationship between HS and OSA severity, and to compare HS in this clinical cohort with a general population sample (N = 5000). Patients referred to an overnight sleep study due to suspected OSA, whom also responded to the SF-36 questionnaire, were included (N = 418). Of these, 194 showed normal findings, while 111, 60 and 53 demonstrated mild, moderate and severe OSA, respectively. Mean age was 47.5 (SD 11.9) and 69% were males. Only the mental health scale (p = 0.015) and mental component summary score (p = 0.023) were associated with OSA severity. This association, however, disappeared in multivariable analysis. All SF-36 scores in the sleep study group were lower than that of the general population sample, in both unadjusted and multivariable linear regression analysis. In this study, there was a lack of association between OSA severity and general HS. However, as a whole, patients in this clinical population referred to an overnight sleep study due to suspected OSA had impaired HS on all scales compared to a general population, with greatest differences in the vitality domain.
Highlights
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of complete and partial airway obstruction, which may result in an increased risk of cardiovascular diseases and metabolic disorders and subsequently have an adverse effect on quality of life[1]
We focused on the Social functioning (SF)-36 domains of physical functioning and vitality, which in previous studies have been associated with sleep disorders and expected to be most sensitive to symptoms of OSA10,12,27, as well as the two component summary scores, physical component summary (PCS) and mental component summary (MCS)
In this study of patients with suspected obstructive sleep apnea (OSA) referred to an overnight sleep study, we could not show an overall difference in SF-36 scale scores according to OSA severity after adjusting for confounders
Summary
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of complete and partial airway obstruction, which may result in an increased risk of cardiovascular diseases and metabolic disorders and subsequently have an adverse effect on quality of life[1]. Males with mild OSA have shown poorer scores for the domains of role emotional, role physical, vitality and mental health when compared to patients with normal findings[13]. In another clinical population sample, patients with mild and moderate OSA scored lower in the domains of physical functioning and role physical, www.nature.com/scientificreports/. The objective of this study was to use the SF-36 to: (1) estimate the dose response relationship between HS and OSA severity, grouped as mild, moderate or severe OSA, and (2) to compare HS in this clinical cohort with a general population sample
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