Abstract
BackgroundDue to the rise in incidence, the long term effect of sepsis are becoming more evident. There is increasing evidence that sepsis may result in an impaired health related quality of life. The aim of this study was to investigate whether health related quality of life is impaired in sepsis survivors and which clinical parameters are associated with the affected health related quality of life.MethodsWe analyzed 880 Short Form 36 (SF-36) questionnaires that were sent to sepsis survivors who participated in the Prehospital Antibiotics Against Sepsis (PHANTASi) trial. These questionnaires were sent by email, 28 days after discharge. Data entry and statistical analyses were performed in SPSS. The data from the general Dutch population, was obtained from the Netherlands Cancer Institute (NKI-AVL) and served as a control group. Subsequently, 567 sepsis survivors were matched to 567 controls. Non-parametric Wilcoxon signed-rank test was performed to compare these two groups. Within the group, we sought to explain the diminished health related quality of life by factor analysis.ResultsWe found that sepsis survivors have a worse health related quality of life compared to the general Dutch population. This negative effect was more evident for the physical component than the mental component of health related quality of life. We found that health related quality of life was significantly altered by advancing age and female sex. We also found that the total length of stay (in the hospital) and (previous) comorbidity negatively affect the physical component of health related quality of life.ConclusionIn our study we found that health related quality of life in sepsis survivors, 28 days after discharge, is severely diminished in comparison with the general Dutch population. The physical domain is severely affected, whereas the mental domain is less influenced. The length of stay, comorbidity, advancing age and female sex all have a negative effect on the Physical Component Scale of the health related quality of life.
Highlights
Sepsis is a syndrome of physiologic, pathologic and biochemical abnormalities induced by infection [1]
We found that sepsis survivors have a worse health related quality of life compared to the general Dutch population
We found that health related quality of life was significantly altered by advancing age and female sex
Summary
Sepsis is a syndrome of physiologic, pathologic and biochemical abnormalities induced by infection [1]. The worldwide incidence of sepsis is rising. This is caused by several factors, such as: the ageing population, antibiotic resistance, increased use of chemo-and immunotherapy and improved recognition [2],[1]. Previous studies found that in-hospital septic shock mortality decreased from 54.9% to 50.7% from 2005 to 2014 [4]. This decrease in case fatality can be attributed to improved recognition, clinical advances including early goal-directed therapy and mortality reduction campaigns [5]. Due to the rise in incidence, the long term effect of sepsis are becoming more evident. The aim of this study was to investigate whether health related quality of life is impaired in sepsis survivors and which clinical parameters are associated with the affected health related quality of life
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
