Health-related quality of life, fatigue and health behaviours in Australian adolescent and young adult cancer survivors.

Abstract

Current knowledge of the long-term health behaviours and well-being of adolescent and yong adult (AYA) cancer survivors is limited. The aim of this study was to evaluate the health behaviours of AYA cancer survivors compared to Australian normative data and describe their health-related quality of life (HR-QoL) and levels of fatigue. A cross-sectional online survey of participants aged 15-25years at diagnosis and 2-7years post treatment completion was conducted at a comprehensive cancer centre. Validated questionnaires assessed health behaviours and functioning including current physical activity (PA) levels, diet quality, fatigue (FACIT-F) and HR-QoL (AQoL-6D, Short Form 36v2 [SF-36v2]) were compared to Australian normative data. Ninety individuals completed the survey (26% response rate) with a mean age of 25.4years and median time post treatment of 61months (24-85months). Compared to normative data, a higher proportion of AYA cancer survivors was consuming the recommended daily serves of fruit and vegetables (16.7% vs. 3.9%, p<.0001), had a lower presence of overweight or obesity (46.7% vs. 57.7%, p=.04) and lower percentage of current smokers (2.2% vs. 16.7%, p<.0001). However, AYA cancer survivors reported increased fatigue (t[df=596]=-4.1, p<.0001) and reduced HR-QoL compared to normative data (t[df=533]=9.2, p<.0001) along with a higher proportion suffering from one or more chronic health conditions (65% vs. 40%, p<.0001). AYA cancer survivors from a single Australian institution, who were on average 5years post treatment, exhibited better health behaviours compared to Australian normative data, but still below recommended guidelines. However, they continue to experience issues with fatigue and reduced HR-QoL, especially in those not meeting the PA guidelines.