Health-related quality of life and medication adherence of people living with epilepsy in Pakistan: A cross-sectional study.

Abstract

The primary purpose of this study was to determine adherence and health-related quality of life (HRQoL) in PWE. Secondary aims were to assess association between adherence and HRQoL and determine predictors of HRQoL in PWE in Pakistan. A descriptive cross-sectional study was conducted among PWE receiving treatment from two tertiary care hospitals of Pakistan. The HRQoL and adherence were assessed with Urdu versions of Quality of Life in Epilepsy-31 (QOLIE-31), and Medication Adherence Rating Scale (MARS). Relationship between HRQoL and adherence was assessed by Pearson's product-moment correlation coefficient. Forced entry multiple linear models were used to determine relationship of independent variables with HRQoL. 219 PWE with a mean (±standard deviation) age, 34.18 (±13.710) years, participated in this study. The overall weighted mean HRQoL score was (51.60±17.10), and mean score for adherence was 6.17 (±2.31). There was significant association between adherence and HRQoL in PWE (Pearson's correlation=0.820-0.930; p≤.0001). Multiple linear regression found adherence (B=16.8; p≤.0001), male gender (B=10.0; p=.001), employment status (employed: B=7.50; p=.030), level of education (Tertiary: B=0.910; p=.010), duration of epilepsy (>10 years: B=-0.700; p≤.0001), and age (≥46 years: B=-0.680; p≤.0001), and ASM therapy (polypharmacy: B=0.430; p=.010) as independent predictors of HRQoL in PWE from Pakistan. The findings suggest PWE from our center have suboptimal adherence which affects HRQoL. Independent factors such as male gender, employment status and duration of epilepsy are predictors of HRQoL.