Abstract
The aim of the study was to investigate the association between insulin resistance (IR) and health-related quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up. A randomized epidemiological study was performed with 835 subjects. The following data were examined using questionnaires: sociodemographic characteristics, behavioural factors, HRQoL and self-perceived health. Fasting blood samples were drawn from all participants, and biochemical tests were performed for glucose and insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting for various factors, logistic regression analysis showed that within 10 years, there was a significantly higher chance of deteriorating HRQoL in the areas of physical functioning (odds ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL, and as they age, they are significantly more likely to have a deterioration in their HRQoL than people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.
Highlights
The aim of the study was to investigate the association between insulin resistance (IR) and healthrelated quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up
Systolic and diastolic arterial blood pressure was greater in participants with IR
After adjusting for year, sex, age, IR, marital status, education, employment, self-perceived health, frequent stressful events, depressed mood, alcohol use, smoking, illness during the past 12 months, and body mass index, subjects with IR had a significantly higher chance of deteriorating HRQoL in the dimensions of physical functioning, emotional role limitations, social functioning, pain and general health perception after a 10-year period, as seen in Model 2 (Table 4). This longitudinal study regarding HRQoL among individuals in the western part of Lithuania indicated that decreases in HRQoL were significantly related to IR, as evaluated by homeostasis model assessment of IR (HOMA-IR)
Summary
The aim of the study was to investigate the association between insulin resistance (IR) and healthrelated quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up. In subjects with IR, after adjusting for various factors, logistic regression analysis showed that within 10 years, there was a significantly higher chance of deteriorating HRQoL in the areas of physical functioning (odds ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). Using the HOMA-IR and the SF-36 health survey, crosssectional data from 1212 participants in the Hertfordshire Cohort Study revealed that IR was associated with poor health-related quality of life (HRQoL) in domains of physical health but not in domains of mental health[18]. IR was found be strongly correlated with an estimated measure of quality of life in patients with coronary heart disease but without known D M19
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