Health Potential of Clery Strawberries: Enzymatic Inhibition and Anti-Candida Activity Evaluation.

Francesco Cairone,Anastasia Orekhova,Maria Antonietta Casadei,Giovanna Simonetti,Stefania Cesa,Gokhan Zengin

doi:10.3390/molecules26061731

Francesco Cairone, Anastasia Orekhova + Show 4 more

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https://doi.org/10.3390/molecules26061731

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Journal: Molecules (Basel, Switzerland)	Publication Date: Mar 19, 2021
Citations: 5	License type: CC BY 4.0

Affiliation: Sapienza University of Rome

Abstract

Strawberries, belonging to cultivar Clery (Fragaria × ananassa Duchesne ex Weston) and to a graft obtained by crossing Clery and Fragaria vesca L., were chosen for a study on their health potential, with regard to the prevention of chronic and degenerative diseases. Selected samples, coming from fresh and defrosted berries, submitted to different homogenization techniques combined with thermal and microwave treatments, had been previously analyzed in their polyphenolic content and antioxidant capacity. In the present work, these homogenates were evaluated in relation to their enzymatic inhibition activity towards acetylcholinesterase and butyrylcholinesterase, α-amylase, α-glucosidase and tyrosinase. All these enzymes, involved in the onset of diabetes, and neurodegenerative and other chronic diseases, were modulated by the tested samples. The inhibitory effect on tyrosinase and cholinesterase was the most valuable. Antifungal activity against Candida albicans, recently shown to play a crucial role in human gut diseases as well as diabetes, rheumatoid arthritis and Alzheimer’s disease, was also shown in vitro and confirmed by the in vivo text on Galleria mellonella. Overall, the obtained results confirm once again the health potential of strawberries; however, the efficacy is dependent on high quality products submitted to correct processing flow charts.

Highlights

Many recent reports show that the onset and growth of metabolic syndrome, diabetes, inflammation, cancer, neurological and cardiovascular diseases are etiologically correlated to the reduced consumption of antioxidant molecules contained in fruits and greens
The well-recognized health potential associated with the daily consumption of vegetables and fruits has represented the object of interest of many studies carried out during the last two decades [1]
Strawberry juice and blackberries was carried out by Patras et al [24] and Karacam et al [25], and we have conducted analogue experiments on blueberries and goji berries [26,27]. These papers show that quality parameters are deeply influenced by thermal, microwave and homogenization treatments

Summary

Introduction

Many recent reports show that the onset and growth of metabolic syndrome, diabetes, inflammation, cancer, neurological and cardiovascular diseases are etiologically correlated to the reduced consumption of antioxidant molecules contained in fruits and greens. Represent, respectively, the wild type and a species largely cultivated worldwide, both appreciated for their attractive characteristics, color, fragrance, taste, and high vitamin and mineral content. These promising characteristics have prompted cultivators to trial many new crop crossings. Many recent studies and reviews regarding the health benefits exerted by berries in general, and strawberries in particular, underline the special role of these fruits in the prevention of inflammation and cell damage [3,4]. It is well known that inflammation is dramatically correlated with cancer and chronic diseases [5] and that gut microbiota-derived products can induce inflammation and contribute to metabolic and degenerative illnesses [6]

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