Abstract
Results Among 54 patients, 22 (40.7%) were AHR-negative. The considerable factors for the maintenance of AHR is male sex, presence of dyspnea at initial presentation and high dose inhaled corticosteroid plus long acting beta agonist at initial presentation (respectively, p < 0.05). Age, symptoms other than dyspnea, blood tests, results of the spirometry, diagnostic methods at presentation and time intervals from diagnosis to follow-up tests showed no difference between AHR-negativity and AHR-positivity. Multivariable analyses failed to show a statistical significance in the two groups. Conclusions In mild asthmatics, about 40% might show no AHR, the clinical remission of the disease. Changing AHR status in mild asthma while undergoing medical treatment is not predictable, so that cessation of regular controller medication might be advocated, and then a reassessment of AHR should be mandatory.
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