Health effects of moniliformin: a poorly understood Fusarium mycotoxin

Abstract

The contamination of the food and feed chain with mycotoxins and the subsequent threat to human health and animal welfare is evident. Today mycotoxin research is still strongly focused on mycotoxins such as aflatoxins, ochratoxin A and for Fusarium fungi mainly the trichothecenes deoxynivalenol (DON) and T-2 and HT-2 toxins. However, fungi of the Fusarium genus are clearly capable of synthesising other mycotoxins as well, including moniliformin (MON). The occurrence of MON is worldwide and the levels in grains vary from below the limit of quantification to the highest detected value in maize intended for human consumption being close to 20 mg/kg. In Finland and Norway, the reported levels are typically a few hundreds of micrograms per kilogram. The toxicology of MON is not well understood. It is characterised by major species differences but typically MON evokes myocardiac damage. For MON, No Observed Adverse Effect Level (NOAEL) has not been established and a provisional Tolerable Daily Intake (pTDI) value has not been proposed. In our risk assessment, we applied a NOAEL value of 10 mg/kg bw/day which is based on our unpublished subchronic exposure experiments. By applying this value in the risk assessment combined with the estimated intakes from food in Finland and Norway, it seems that MON per se does not pose a clear threat to human health at current levels. On the other hand, one needs to bear in mind the concurrent exposure to other mycotoxins and the fact that the risk assessment of mycotoxin mixtures are in their infancy.