Abstract
This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that investigate the effects of GSSE on diabetes mellitus, cardiovascular disease and cancer, its neuroprotective effect, and its effects on the gastrointestinal tract and other health complications related to these diseases. The results of the studies confirm that the anti-inflammatory, antiapoptotic, and pro-proliferative effects of “Vitis vinifera L.” seed extract reduce the level of oxidative stress and improve the overall lipid metabolism.
Highlights
The grapevine (Vitis vinifera L.) is an important cultivated plant that has long been studied due to its positive effects on consumer health
This study examined the role of oxidative stress and the protective effects of grape seed proanthocyanidin extract (GSPE) on urethral dysfunction using a streptozotocin-induced diabetes mellitus rat model
The findings of this study demonstrated that GSPE protects the urethral function in rats with diabetes mellitus by modulating the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling pathway
Summary
The grapevine (Vitis vinifera L.) is an important cultivated plant that has long been studied due to its positive effects on consumer health. The seeds of this plant contain a wide range of biologically active components [1] that help to neutralize the adverse effects of free radicals. Grapevine seeds contain a number of biologically active substances that, even in low concentrations, affect life processes, positively, and negatively. These substances are isolated from natural sources, and they can differ significantly from each other in their structure. The present study primarily includes research findings from the years 2002–2020
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