Health ecology: factors of spread and consequences of viral hepatitis manifestation

Ludmila Vetrova,Elena Khorolskaya,Irina Sagalaeva,Tatyana Pogrebnyak,Darya Maslova,I Spichak,O Lebedeva

doi:10.1051/bioconf/20213004009

Abstract

The features of viral hepatitis B (HB) and C (HC) in the initial making of these diagnoses in three age groups of men and women (25-30, 31-55 years old for women and 31-60 years old for men, over 55 for women and 60 years old for men) were studied. High levels of bilirubin in the blood serum in all groups indicated damage of the functions of hepatocytes, especially in men with hepatitis B, in women with hepatitis C. The high ALT activity indicated an increase in cytolytic processes in liver hepatocytes in all groups with viral HB and HC, especially in men of the younger group, in women of the younger and middle-aged groups. The high concentration of AST indicated early stages of HC infection in all age groups, especially in the younger group of men with liver, heart, kidney and muscle damage. A positive thymol test in all groups of men and women with HB and HC indicated a shift in the protein balance along the path of pathologically enhanced synthesis of γ-globulins in hepatocytes and the removal of albumins from the body. The concentration of β-lipoproteins in the blood serum only in men of the younger group with hepatitis C corresponded to the norm, in other groups with HB or HC this parameter exceeded it by an average of 1.5 times, noting a violation of lipid metabolism in hepatocytes of the liver.

Highlights

The analysis of publication activity on the study of chronic viral hepatitis B (CHB) and C (CHC) shows the interest of researchers in this problem, since the receipt of new data opens up a wide prospect for expanding and deepening knowledge in the field of features of the manifestation of viral hepatitis [1, 2]
Features of manifestation in men and women infected with VHB or VHC, who have a positive result for the presence of their corresponding markers in their blood serum, are presented in table I
High concentration and activity of ALT aminotransferase in blood serum indicated enhanced cytological processes in liver hepatocytes in all groups of men and women with viral VHB and HC, especially pronounced in men of the younger group, women of the younger and middle-aged groups

Summary

Introduction

The analysis of publication activity on the study of chronic viral hepatitis B (CHB) and C (CHC) shows the interest of researchers in this problem, since the receipt of new data opens up a wide prospect for expanding and deepening knowledge in the field of features of the manifestation of viral hepatitis [1, 2]. All types of viral hepatitis are registered in Russia They occupy one of the leading places in human infectious pathology [3, 5]. Experts attribute Russia to regions of the world with low endemicity for hepatitis E, with average-for hepatitis A, B, C, D, assessing these data to a certain extent conditionally. Since their accuracy depends on the quality of diagnostics and completeness of registration of all cases of the population infection [5]. The prevalence of viral hepatitis in Russia is estimated by the official indicators of registration of the incidence of acute hepatitis CHA, CHB and CHC in the population and by the frequency of detection of serological markers of infection [6, 7]

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Conclusion