Abstract

Thirty-four patients undergoing bone marrow transplantation or remission induction for acute non-lymphocytic leukemia were the subjects of a study to determine whether outcome of infection (survival, death) could be related to total complement (TC), complement components, or C-reactive protein (CRP). Serum samples were obtained when the neutropenic patients became febrile, and at intervals thereafter. Significant differences were found between final total serum complement levels, the C3 component of complement, and the C-reactive protein. Multivariate logistic regression demonstrated a significant relationship between the final C3 complement and C-reactive protein levels and the outcome of infection. Changes between initial and final values were also predictive of outcome, suggesting that the magnitude and direction of changes in these measurements may assist the clinician in assessing the success of his prescribed antibiotic therapy. Our data suggest that a test battery comprising serial TC, C3, and CRP measurements may have more predictive potential than each test performed independently.

Highlights

  • Health care quality is a level of value provided by any health care resource, as determined by some measurement

  • Many are unfamiliar with strategies to reduce the risk of harm

  • Diagnostic errors – defined as inaccurate or delayed diagnoses – account for an estimated 10% of patient deaths, hundreds of thousands of adverse events in hospitals each year and are a leading cause of paid medical malpractice claims a blue ribbon panel of the Institute of Medicine (IOM) said in its report

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Summary

Introduction

Health care quality is a level of value provided by any health care resource, as determined by some measurement. Patient safety is a subject that traverses all medical specialties and affects every health-care professional. A number of practicing physicians, remain unaware of the extent of the problem, the impact on patients, and the burden on the health-care system.

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