Abstract
Short-term administration of Lactobacillus gasseri CP2305 improves stress-associated symptoms and clinical symptoms in healthy young adults and in patients with irritable bowel syndrome, respectively. We evaluated the efficacy and health benefits of the long-term use of a tablet containing heat-inactivated, washed Lactobacillus gasseri CP2305 (CP2305) in healthy young adults. Sixty Japanese medical students (41 men and 19 women) preparing for the national examination for medical practitioners ingested CP2305-containing or placebo tablets once daily for 24 weeks. Intake of the CP2305 tablet significantly reduced anxiety and sleep disturbance relative to placebo, as quantitated by the Spielberger State-Trait Anxiety Inventory and the Pittsburgh Sleep Quality Index. Single-channel sleep electroencephalograms show that CP2305 significantly shortened sleep latency and wake time after sleep onset and increased the delta power ratio in the first sleep cycle. CP2305 also significantly lowered salivary chromogranin A levels compared with placebo. Furthermore, 16S rRNA gene sequencing of participant feces demonstrated that CP2305 administration attenuated the stress-induced decline of Bifidobacterium spp. and the stress-induced elevation of Streptococcus spp. We conclude that the long-term use of CP2305-containing tablets may improve the mental state, sleep quality, and gut microbiota of healthy adults under stressful conditions.
Highlights
IntroductionThe bidirectional communication system between the gut and brain, the gut–brain axis, has been shown to have a crucial role in the maintenance of intestinal homeostasis and brain function [1,2]
The bidirectional communication system between the gut and brain, the gut–brain axis, has been shown to have a crucial role in the maintenance of intestinal homeostasis and brain function [1,2].The microbial community of the gastrointestinal tract affects this communication system through immune, endocrine, and neural pathways [3]
This study aimed to assess whether long-term use of a tablet containing heat-inactivated, washed, and dried Lactobacillus gasseri CP2305 would have health benefits in young adults preparing for the national examination for medical practitioners
Summary
The bidirectional communication system between the gut and brain, the gut–brain axis, has been shown to have a crucial role in the maintenance of intestinal homeostasis and brain function [1,2]. The microbial community of the gastrointestinal tract affects this communication system through immune, endocrine, and neural pathways [3]. Several lines of evidence suggest that the gut microbiome has a significant impact on brain function, affecting mood, recognition, and behavior [4]. The concept of the gut–brain axis has expanded to the “microbiota–gut–brain axis” [4]. Probiotics, defined as live microorganisms which confer a health benefit to the host when administered in adequate amounts [5], have been shown to interact with the brain. Animal studies have reported that probiotic administration modulates the hippocampus-mediated
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
