Abstract
Medinilla speciosa (local name: parijoto) has many pharmacological benefits, including for treating female infertility. This study aimed to identify bioactive compounds of the aqueous and ethanolic extracts of Medinilla speciosa; to find information on their pharmacological benefits, and to do its docking profile with the protein phosphatase1, which is associated with the enhancement of female fertility. Articles were searched from PubMed. The components of Medinilla speciosa were analyzed with LC-MS/MS. In silico study was conducted based PubChem, Protein Data Base, and Swiss ADME. Pyrx 0.8 and Discovery Studio Visualizer v21.1 were used to predict the interaction. Four flavonoids were identified, namely fisetin, robinetin, luteolin, and kaempferol. Except for robinetin, they exist in glycosidic form. One polyphenol, ellagic acid, was also identified. Literature studies showed they have various pharmacological benefits, such as antioxidants, anti-inflammation, anticancer, antidiabetes, organ protection, and antimicrobial. However, no information is available on its potential for fertility enhancement. Docking analysis showed that the bioactive compounds interact with the A and C chains of the catalytic domain of protein phosphatase 1 (PP1). Aqueous and ethanolic extracts of Medinilla speciosa possess fisetin, robinetin, luteolin, kaempferol, and ellagic acid that bind to catalytic chains of protein phosphatase 1.
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