Abstract

The blood-brain barrier (BBB) is a cellular layer in the blood vessels of the brain. The blood-brain barrier partitions the circulating blood from the brain tissue proper. It regulates the passage of vital substances and nutrients into brain tissues, and the passage of carbon dioxide and metabolic waste products out of brain tissues. The selective passage prohibits harmful toxins from infiltrating the brain, and also excludes many drugs and therapeutic agents from reaching brain tissues.

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