Abstract
This chapter describes how the profile of physical and mental health and well-being changes across adolescence. The biological context of healthy adolescent growth and development is reviewed, including secular patterns of puberty and brain maturation. The structural and social determinants of adolescent health are then described. Adolescent health outcomes, including patterns of risk behaviors, emerge from the interaction between biological influences and social health determinants. Estimates of mortality and disability-adjusted life years are used to describe three patterns of adolescent health and well-being that vary by age, sex, and national wealth. Globally, the burden of disease increases across adolescence, varying markedly between and within countries. Comprehensive, multisectoral, evidence-informed actions are required that match these conspicuous adolescent health problems, emerging health risks, and major social determinants. Such actions, including quality education and health services, differ greatly from those that benefit younger children yet have similarly high benefit–cost ratios.
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