Health and functional status of long-term adult medulloblastoma/PNet survivors: A report from the Childhood Cancer Survivor Study.

Abstract

9515 Background: Medulloblastoma is the most common malignant childhood CNS tumor. Survival rates increased from 40% to 70% during the past 30 years. The long-term risks of chronic medical conditions, adverse health status, and reduced psychosocial functioning in aging survivors of childhood medulloblastoma/PNET are not known. Methods: Using the Childhood Cancer Survivor Study cohort, we analyzed the long-term outcomes of 380 5+ year survivors of medullobastoma/PNET (median age at last follow-up: 30 years, range 7-53), diagnosed between 1970-1986. A sibling cohort (n=4031) served as a comparison population. Neurological outcomes and cataracts were analyzed as time-to-event data with cumulative incidence, with Cox regression models used to calculate hazard ratios (HR) and 95% confidence intervals (CI). Memory complications, educational status, marital status, independent living, employment status, income, and fertility were assessed cross-sectionally using generalized linear models. Comparisons were adjust...