Abstract
Healing the gap: the evolution of esophageal substitute and quality of life in patients undergoing total pharyngolaryngoesophagectomy with reconstruction
Highlights
There are approximately 80,000 patients with newly diagnosed hypopharyngeal cancer and 35,000 deaths annually in the world[1]
We retrospectively reviewed the records of all patients who underwent total pharyngolaryngoesophagectomy (TPLE) between January 2012 and December 2020
A total of 40 patients undergoing oncologic pharyngolaryngoesophagectomy were enrolled in this study
Summary
There are approximately 80,000 patients with newly diagnosed hypopharyngeal cancer and 35,000 deaths annually in the world[1]. In Taiwan, 1209 patients were newly diagnosed as having hypopharyngeal cancer in 2018, and the age-standardized incidence rate was 3.25 per 100,000 person-years. Hypopharyngeal cancer tends to be locally advanced at diagnosis because of the lack of alarming symptoms. Fewer than 50% of hypopharyngeal cancers are confined to the hypopharynx and more than 80% of patients have stage III or IV disease at diagnosis[2,3,4]. Because of its late diagnosis with high rate of metastasis, the disappointing survival and functional outcome were well-known. Organ-preserving multi-modality treatment for hypopharyngeal cancer has been prevailing, surgical resection continues to be the standard therapeutic choice[5,6,7]
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