Abstract
The aims of this research was to find out the healing process of second degree burn in rats (Rattus norvegicus) using ambarella leaf (Spondias dulcis F.) and vaselin on histopathologically. The research consisted of 4 treatment groups and 3 rats each, P1(double distilled water), P2 (ambarella leaf + double distilled water), P3 (vaselin), and P4 (ambarella leaf + vaselin). Treatment was done twice a day for 21 days. The research parameters are inflammatory reactions and distribution of collagen tissue. Data were analyzed descriptively. The results showed that on day 7, P1 and P3 many infiltration of inflammatory cells, hemorrhage and edema, on P2 and P4 here more infiltration of inflammatory cells, hemorrhage and edema. On the day 14th of many inflammatory cell infiltration, collagen tissue diffuse very thin on were described P1 and P3, and visible presence of new blood vessels was found on P4. On day 21th infiltration of inflammatory cells still present on (P1), there were a lot of new blood vessels on P2, there has been a process of epithelialization (P3), epidermis formed and collagen tissue spread very densely on P4. Based on the results of this study it can be concluded that administration of ambarella leaf and vaselin can speed up the healing process of burns in rats compared with other treatments.Key words: ambarella leaf, burn, vaselin
Highlights
The aims of this research was to find out the healing process of second degree burn in rats (Rattus norvegicus) using ambarella leaf (Spondias dulcis F.) and vaselin on histopathologically
The results showed that on day 7, P1 and P3 many infiltration of inflammatory cells, hemorrhage and edema, on P2 and P4 here more infiltration of inflammatory cells, hemorrhage and edema
Buku Ajar Ilmu Bedah : Luka Bakar
Summary
Saponin dan tanin diduga sebagai senyawa antibakteri pada daun kedondong, selain itu saponin juga memicu pertumbuhan jaringan kolagen (Inayati, 2007). Ada bahan lain yang dapat digunakan sebagai campuran daun kedondong yaitu menggunakan vaselin flavum. Dalam industri farmasi vaselin flavum banyak digunakan sebagai bahan dasar salep hidrokarbon (dasar bersifat lemak) dipakai terutama untuk efek emolien (melindungi kulit). Dasar salep ini bertahan pada kulit untuk waktu yang lama, tidak mudah menguap ke udara dan sukar dicuci sehingga memperpanjang kontak obat dengan kulit, kerjanya hanya sebagai penutup saja. Informasi tersebut mendorong peneliti untuk melakukan penelitian dengan memanfaatkan daun kedondong dan vaselin yang berkhasiat untuk mempercepat penyembuhan luka bakar pada tikus putih. Hasil penelitian diharapkan akan memberi informasi ilmiah untuk menjadikan daun kedondong dan vaselin sebagai salah satu alternatif pengobatan luka bakar
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