Abstract
ObjectivesThe aim of this randomized controlled clinical trial was to compare the clinical outcomes obtained in intrabony defects following regenerative periodontal surgery using the single-flap approach (SFA) in conjunction with either hyaluronic acid (HA) or enamel matrix derivative (EMD).Materials and methodsThirty-two intrabony defects in 32 healthy subjects were randomly assigned: HA (test group) or EMD (control group). Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), and bleeding on probing (BOP) were recorded at baseline,12, 18, and 24 months after surgery.ResultsAt 24 months, both treatments resulted in statistically significant clinical improvements evidenced by PD-reduction and CAL-gain (p<0.001). The mean CAL-gain was 2.19±1.11 mm in the test and 2.94±1.12 mm in the control sites (p=0.067). PD-reduction was statistically significantly higher for the control group (4.5±0.97 mm) than the test group (3.31±0.70 mm), (p=0.001). CAL-gain ≤ 3 mm was observed in 87.5% and in 62.5% of the test and control sites, respectively. Test sites showed slightly lower REC values than the control sites. No statistically significant differences were found for BOP between treatments.ConclusionsThe present findings indicate that both treatments led to statistically significant clinical improvements compared to baseline, although the application of EMD resulted in statistically significantly higher PD-reduction compared to the use of HA.Clinical relevanceThe use of HA in conjunction with a SFA resulted in significant PD-reduction and CAL-gain, pointing to the potential clinical relevance of this material in regenerative periodontal surgery.
Highlights
Periodontitis may lead to the formation of intrabony defects, defined as specific osseous defects with a base apical to theClin Oral Invest (2021) 25:5095–51075]
The results have shown that Hyaluronic acid (HA) in conjunction with access flap may provide positive effects demonstrated by an additional reduction in probing depth (PD) and clinical attachment level (CAL) gain in intrabony defects compared with access flap alone [24, 25]
According to the best of our knowledge, until now, no clinical studies have evaluated the effects of HA when used in conjunction with reconstructive periodontal surgery in intrabony defects, and compared those to the outcomes obtained following the use of enamel matrix derivative (EMD). The aim of this randomized controlled clinical trial was to compare the clinical outcomes obtained in intrabony defects following regenerative periodontal surgery using the single-flap approach (SFA) [6] in conjunction with either HA or EMD
Summary
Periodontitis may lead to the formation of intrabony defects, defined as specific osseous defects with a base apical to theClin Oral Invest (2021) 25:5095–51075]. It was demonstrated that HA has bacteriostatic [9, 10], fungostatic [11], antiinflammatory [12], anti-edematous [13], osteoinductive [12, 14,15,16], and pro-angiogenetic [17] properties. It plays a significant role in inflammation, clot and granulation tissue formation, cell migration and differentiation during tissue formation, and repair of both soft and hard tissues [18, 19]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
