Abstract
Experiments were undertaken to assess the healing effect of bee venom (BV) cream to full-thickness skin wound in rabbits. BV cream was compared with silver sulfadiazine (SS) as a topical medicament against a control on experimentally created full-thickness wounds. Two wounds measuring 2 × 2 cm were created bilaterally (4 wounds/rabbit) on the dorsolateral aspect of the trunk of 7 New Zealand white. Wound treatments were evenly distributed 4 sites, using a Latin square design. The contact layer of wounds was treated with physiological saline (control), SS cream and BV cream during 28 days. Wound healing was assessed on the basis of scab hardness, wound exudates, wound area, unepithelialized granulation tissue and histopathological findings. Topical application of BV and SS creams to wound reduced inflammation, debrided necrotic tissue and promoted granulation and epithelialization. Wound healing was statistically significantly faster in BV and SS treatments compared to the control (P
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