Abstract
Headache is a common complaint in children with sickle cell disease. Dowling et al conducted a planned secondary analysis from the Silent Infarct Transfusion Trial to determine whether recurrent headache or, more specifically, migraine were predictive of silent cerebral infarction in children with sickle cell disease. In a cross-sectional study of 872 children, about one-third had headaches and 15% had migraines. Asymptomatic cerebral infarcts were not more likely in patients with recurrent headaches or migraine. As a take-home point, the authors note that neuroimaging may not be needed for children with sickle cell disease who have recurrent headache without additional risk factors or neurologic findings. Interestingly, recurrent headaches and migraine were associated in patients with sickle cell disease with a higher rate of overall painful events requiring hospitalization.Article page 1175▶ Headache is a common complaint in children with sickle cell disease. Dowling et al conducted a planned secondary analysis from the Silent Infarct Transfusion Trial to determine whether recurrent headache or, more specifically, migraine were predictive of silent cerebral infarction in children with sickle cell disease. In a cross-sectional study of 872 children, about one-third had headaches and 15% had migraines. Asymptomatic cerebral infarcts were not more likely in patients with recurrent headaches or migraine. As a take-home point, the authors note that neuroimaging may not be needed for children with sickle cell disease who have recurrent headache without additional risk factors or neurologic findings. Interestingly, recurrent headaches and migraine were associated in patients with sickle cell disease with a higher rate of overall painful events requiring hospitalization. Article page 1175▶ Headache and Migraine in Children with Sickle Cell Disease Are Associated with Lower Hemoglobin and Higher Pain Event Rates But Not Silent Cerebral InfarctionThe Journal of PediatricsVol. 164Issue 5PreviewTo identify risk factors for headache and migraine in children with sickle cell disease and test the hypothesis that either or both are independently associated with silent cerebral infarcts. Full-Text PDF
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