Abstract
There is a scarcity of longitudinal data that support the observation that overuse of medications for acute headache is a risk factor for increasing frequency of headache in migraineurs. In a recent population-based survey, the annual incidence of transformed migraine (TM) was 2·5%.1 Individuals who used medications that contain barbiturates or opiates were at increased risk of developing TM, regardless of how often those drugs were used (barbiturates: OR 2·06, 95% CI 1·3–3·1; opiates 1·98, 1·4–2·2).
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