Abstract
We report a head-mountable CMOS camera for recording rapid neuronal activity in freely moving rodents using fluorescent activity reporters. This small, lightweight camera is capable of detecting small changes in light intensity (0.2% Δ I/ I) at 500 fps. The camera has a resolution of 32 × 32, sensitivity of 0.62 V/lx s, conversion gain of 0.52 μV/e − and well capacity of 2.1 Me −. The camera, containing intensity offset subtraction circuitry within the imaging chip, is part of a miniaturized epi-fluorescent microscope and represents a first generation, mobile scientific-grade, physiology imaging camera.
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