Abstract
Introduction: Traumatic brain injuries (TBI) are among the worst consequences and are the major causes of death and disability worldwide. It is considered as silent epidemics affecting individuals of all the ages and one of the major burden of neorological disease. Hence, TBIs are often overlooked and are sometimes called “the neglected disease of modern society”. Presenting GCS is the best predictor of outcome.
 Objective: The present study aims to portray the epidemiology, clinical profile, its management, early outcome and to evaluate the outcome predictors in a tertiary care center in eastern part of Nepal.
 Methodology: This is a prospective cross-sectional study conducted at the Department of Neurosurgery, Nobel Medical College Teaching Hospital, Biratnagar, Nepal over the period of 1 year (October, 2016 - December 2017). The primary objective of this study was to review the etiology, clinical profile and early outcome of patients with TBI.
 Results: During the study period, 1056 patients with head injuries were studied. Of these 202 cases required surgical intervention and 32 were excluded. Mean age of the study population was 38.7 years with the male to female ratio of 3.49:1. Road traffic accident was the most common cause of TBI (76%). Overall mortality rate was 11.17%. Unfavorable GOS at discharge was 43.5% and 26.1% at three months follow-up.
 Conclusion: TBI continues to be a significant burden of neurosurgical care in major neurosurgical centers in Nepal. This study contributes data on the etiology and clinical profile of patients with TBI from tertiary care center of Nepal.
Highlights
Trauma c brain injury (TBI) is one of the most devasta ng types of injury
Trauma c brain injuries (TBI) con nues to be a significant burden of neurosurgical care in major neurosurgical centers in Nepal
This study aims to describe the epidemiological, clinical characteris cs, and short-term outcomes of pa ents with TBI admi ed to our ins tute during the study period
Summary
Trauma c brain injury (TBI) is one of the most devasta ng types of injury It affects all ages; majority of road traffic injuries (RTI) occurs in young adults of produc ve age group. It is one of the leading causes of death and disability worldwide.[1] TBI is heterogeneous in terms of pathophysiology, clinical presenta on, and outcome, with case fatality rates ranging between < 1 % in mild TBI up to 40% in severe TBI.[1] Due to rapid surge in urbaniza on, motoriza on and economical libera on, many Asian countries have an increased risk for TBI.[2] In Asian countries, health systems that are o en not able to provide adequate treatment and rehabilita on services to TBI pa ents, creates a 'double risk'. It is important to elucidate the true burden of disease in Asia in order to tailor specific preven on programs aimed at allevia ng this increasing epidemic as TBI has the preventable nature
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