Abstract
Head and Neck Cancer
Highlights
Molecular classification is a very important research area since the traditional clinical-pathological factors do not provide accurate prognostic information
Pentheroudakis et al evaluated the prognostic significance of mRNA levels of the Epidermal Growth Factor Receptor (EGFR) family members HER1-4, the Vascular Endothelial Growth Factors (VEGFs) A, B, C, D, and their receptors VEGFR1, 2, 3 in a small retrospective cohort of head and neck squamous cell carcinoma (HNSCC)
The authors reported that high expression of the VEGF-C/VEGFR3 axis in recurrent HNSCC is associated with neck failure and inferior survival postrelapse but these findings need to be confirmed in large cohorts
Summary
Molecular classification is a very important research area since the traditional clinical-pathological factors do not provide accurate prognostic information. Harari,3 Jan Baptist Vermorken,4 Lisa Licitra,5 and Clarence T. The purpose of this special issue is to provide an update on recent advances in the understanding of head and neck tumorigenesis and their implications in clinical practice.
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