Head and neck alveolar soft-part sarcoma: a review in diagnosis and treatment

Abstract

Head and neck alveolar soft part sarcoma(ASPS) is a rare, distinctive sarcoma, typically occurring in infants and children.It displays a relatively fast clinical course, and the ultimate prognosis is poor and is often characterised by late metastases. It is now clear that they are caused by the formation of an ASPL TFE3 fusion gene,and the new molecular target therapies under study may change the possible approach to primary disease.The diagnosis and treatment of head and neck ASPS are reviewed in this article.