Abstract
Background Dyslipidemias are associated with atherosclerosis and cardiovascular diseases. Recently, non-high-density lipoprotein cholesterol (non-HDL-c) has emerged as a new target for assessment and prediction of risk of cardiovascular disease (CVD) and is closely associated with atheroma plaque progression. Objectives To evaluate associations between HDL-c and non-HDL-c levels and anthropometric and biochemical parameters and with the Castelli risk indexes I and II. Methods 300 randomly selected people were subdivided into two groups: patients with normal values for non-HDL-c and patients with altered values for non-HDL-c. These parameters were analyzed for associations with glycemia, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), Castelli Index I (CI-I), Castelli Index II (CI-II), waist circumference (WC), body mass index (BMI) and presence of metabolic syndrome (MS). Results Glycemia, TC, TG, LDL-c, CI-I, CI-II, WC and BMI were all significantly different between subjects with normal and altered values of HDL-c and non-HDL-c. TC and WC both exhibited significantly higher values among patients with abnormal non-HDL-c when compared to patients with abnormal HDL-c. A significant difference was observed in occurrence of MS among patients with altered values of HDL-c and non-HDL-c. Conclusions Our results show that both HDL-c and non-HDL-c are associated with insulin resistance, dyslipidemia, atherogenic indices, and obesity. There is therefore a need for randomized clinical intervention trials examining the potential role of non-HDL-c as a possible primary therapeutic target.
Highlights
Dyslipidemias are major risk factors for development of atherosclerosis and cardiovascular diseases (CVD)
CVD is strongly associated with the Metabolic Syndrome (MS), which comprises a series of risk factors associated with high morbidity
We observed that altered values for both HDL-c and non-HDL-c were related to higher values for glycemia, total cholesterol (TC), TG, LDL-c, Castelli Index I (CI-I), Castelli Index II (CI-II), waist circumference (WC), and body mass index (BMI)
Summary
Dyslipidemias are major risk factors for development of atherosclerosis and cardiovascular diseases (CVD) They are associated with formation of atherosclerotic plaques, which build up in the intima of the vessel and can influence increased risk for cardiovascular events. Many risk factors play fundamental roles in dyslipidemias, including smoking, obesity, physical inactivity, high blood pressure, insulin resistance, and environmental and genetic influences.[1,2,3,4,5]. Non-High-Density Lipoprotein cholesterol (non-HDL-c) has emerged as a new target for the prevention of cardiovascular events. It reflects the full burden of the cholesterol transported in atherogenic lipoproteins, it is crucial to prediction of CVD risk,[3] and it is closely associated with plaque progression.[4,5]. This study aimed to evaluate associations between HDL-c and non-HDL-c levels and anthropometric and biochemical parameters in a group of patients
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