Abstract
This review is intended to evaluate the research findings and potential clinical applications of drug transport systems, developed based on the concepts of the structure/function and physiological role(s) of high density lipoprotein type nanoparticles. These macromolecules provide targeted transport of cholesteryl esters (a highly lipophilic payload) in their natural/physiological environment. The ability to accommodate highly water insoluble constituents in their core regions enables High density lipoproteins (HDL) type nanoparticles to effectively transport hydrophobic drugs subsequent to systemic administration. Even though the application of reconstituted HDL in the treatment of a number of diseases is reviewed, the primary focus is on the application of HDL type drug delivery agents in cancer chemotherapy. The use of both native and synthetic HDL as drug delivery agents is compared to evaluate their respective potentials for commercial and clinical development. The current status and future perspectives for HDL type nanoparticles are discussed, including current obstacles and future applications in therapeutics.
Highlights
Reviewed by: Daniele Tibullo, University of Catania, Italy Ghanshyam Upadhyay, City College of New York, USA
Reconstituted High density lipoproteins (HDL) can effectively deliver drugs to cancer cells due to their over expression of the scavenger receptor type B1 (SR-B1) receptor. reconstituted HDL (rHDL)-paclitaxel nanoparticles had superior cytotoxicity against prostate, breast and ovarian cancer cells and were better tolerated by mice than either Taxol or Abraxane. rHDL nanoparticles utilized for cytosolic delivery of drugs
Of gold containing rHDL nanoparticles for drug delivery. rHDL nanoparticles containing apolipoprotein A-I (apo A-I) mimetic peptide for drug delivery to malignant tumors
Summary
This review is intended to evaluate the research findings and potential clinical applications of drug transport systems, developed based on the concepts of the structure/function and physiological role(s) of high density lipoprotein type nanoparticles. These macromolecules provide targeted transport of cholesteryl esters (a highly lipophilic payload) in their natural/physiological environment. Even though the application of reconstituted HDL in the treatment of a number of diseases is reviewed, the primary focus is on the application of HDL type drug delivery agents in cancer chemotherapy The use of both native and synthetic HDL as drug delivery agents is compared to evaluate their respective potentials for commercial and clinical development. The current status and future perspectives for HDL type nanoparticles are discussed, including current obstacles and future applications in therapeutics
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