フィールドにおけるHDL-コレステロールとその影響因子の検討

Abstract

Although closed relationship between incidence of IHD and plasma level of HDL cholesterol has been reported recently, few epidemiological investigation based on field study was performed in our country.We performed epidemiological survey and measurement of HDL choleserol utilizing heparinmangon method in a farming village of Takeno school area, Tanushimaru, Fukuoka. The subjects were consisted of 1, 003 male and females, aged 20 to 69 years. Plasma level of HDL cholesterol was contrasted with the presently known influencial factors of HDL cholesterol. Plasma HDL cholesterol level showed normal distribution at the peak value of 40-44mg/dl both female and male. Mean value was 47.02±11.74mg/dl for male and 49.51±11.26 for female showing significantly higher level in female. Although aging did not affect the value both in female and male, female had higher HDL cholesterol level than male in younger age group. Obesity lowered HDL cholesterol level both in female and male, which was also clearly demonstrated by ∑skin-fold.Negative correlationship was found between serum TG and HDL cholesterol both female and male. The more the amount of cigarette smoking, the lower the value of HDL cholesterol. As to alcoholic intake (sake), highest value of HDL cholesterol was found in the group with daily alcoholic consumption of 180 to 360ml. Systolic blood pressure did not affect the value of HDL cholesterol.It was concluded that the presently known influencial factors of HDL cholesterol seemed to affect similarly in our subjects as previously reported.It was also interesting to note the close negative correlationship of HDL cholesterol and ∑skin-fold.