Abstract
We describe a case of precocious sexual development in a 4-year-old boy, which was caused by HCG-secreting hepatoblastoma. The precocious sexual development manifested two months after starting polychemotherapy for hepatoblastoma, which presented as the emergence and rapid progression of pubic hair, low voice, and acceleration of the growth rate and bone age. The size of the testicles remained at the prepubertal level. We, together with oncologists, developed a therapeutic tactics: surgical removal of the tumor after the fourth course of polychemotherapy. Antiandrogenic drugs were not used because of their hepatotoxicity and inefficacy in this clinical situation.
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