Abstract
Objective To investigate the efficacy of HCG and transdermal testosterone therapy for the patients with micropenis.Methods Pediatric patients, who were diagnosed with micropenis,were divided into HCG and testosterone(T) group according to the treatments they received.In group HCG, 1000IU HCG was administered to patients by intramuscular injection twice a week for six weeks.In group T, testosterone cream was applied transdermally twice a day for 2 months.Penile length, testicular size, and sex hormone levels were measured during follow-up.Results No significant differences of penile length and testicular volume was noted between these 2 groups before medication initiation (P>0.05).After treatment, penile length increased in both groups (P 0.05).After treatment, testicular volume markedly increased in HCG group (P 0.05).Conclusions HCG and trandermal testosterone therapy can promote the growth of micropenis in different age without interfering sex hormone levels.Transdermal testosterone therapy is convenient and practical.HCG therapy could be the first choice to increase the testicular volume.Androgen resistance syndrome should be considered when both of the two treatments are ineffective. Key words: Penis; Human chorionic gonadotropin; Testosterone
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