Abstract
BackgroundA recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepatitis B.Methodology/Principal FindingsThree KIF1B polymorphisms (rs8019, rs17401924, and rs17401966) were selected and genotyped in 473 CHB patients and 580 controls with no history of CHB. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression model. None of these three SNPs showed association with CHBs after adjusting for age and gender. Equivalence-based method analysis confirmed the absence of association. In the further haplotype analysis, three common haplotypes were observed in this study population, but no significant effect was also found for haplotypes in the progression to CHB.Conclusions/SignificanceThis study showed the new locus identified for HCC, KIF1B, was not associated with progression to CHB, implying distinct genetic susceptibility factor contributes to the progression from hepatitis B virus infection to HCC. Nevertheless, further comprehensive analyses are warranted to dissect the mechanism.
Highlights
Hepatitis B virus (HBV) infection is one of most challenging global public health problems, with more than 2 billion people infected [1,2]
We conducted a case-control study to firstly investigate whether a new genetic susceptibility locus associated with HBV-related hepatocellular carcinoma (HCC) identified by genomewide association study (GWAS), kinesin family member 1B gene (KIF1B), was involved in development of chronic hepatitis B (CHB)
Since CHB has been verified to be closely associated with HCC, identification of the genetic predictors of CHB development is very important for fighting against HBV-related HCC
Summary
Hepatitis B virus (HBV) infection is one of most challenging global public health problems, with more than 2 billion people infected [1,2]. The environmental factors such as alcohol abuse, infection age, and co-infection with other hepatitis virus unveiled as risk factors of HBV-induced liver disease, genetic factors may influence clinical progression after HBV exposure, which is indicated by familial studies [9]. A recent genomewide association study (GWAS) by Kamatani et al in Japanese population has suggested two SNPs of rs3077 and rs9277535 in HLA-DP region strongly associated with risk of persistent infection of HBV [14]. A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepatitis B
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