Abstract
About 5% of hemoglobin is linked to glucose resulting in a chromatographically distinct hemoglobin component, HbAlc, that is successfully used as a means of metabolic control in diabetic patients. It was the purpose of the present study to clear whether similar hemoglobin alterations can be expected in HFI and G. Minor hemoglobin components of patients with HFI (n=23), G (n=9), type I diabetes (n=14) and healthy controls (n=14) were separated by column chromatography on Bio-Rex 70 resin. In addition, purified hemoglobin was incubated during 4 days at different concentrations of glucose, fructose, galactose, fructose-l-phosphate and galactose-l-phosphate. The following concentrations of minor hemoglobins were abtained: The patients were reportedly well controlled and presented no abnormalities of liver transaminases or blood coagulation at the time of presentation. The in vitro incubation of hemoglobin with glucose resulted in the expected increase of HbAlc. An increase dominating in the HbAlab fractions resulted after exposure to galactose respectively fructose-l-phosphate. We want to advocate the determination of HbAlab as an additional means in the metabolic control of patients with G and HFI.
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