Hba1c Is Associated with Colorectal Adenoma: Results from a Community Hospital Registry

Abstract

Purpose: Previous studies on life style for colorectal cancer risk suggest that glucose and diabetes are associated with colorectal adenomas. We set out to look for associations between HbA1c level and whether this association was greater depending on level of HbA1c.TableTableMethods: The sample included 1,998 consecutive patients who underwent screening colonoscopies from 2009 to 2011 at a community hospital in East Meadow, New York, after excluding those with colon cancer, inflammatory bowel disease, or incomplete colonoscopies. Statistical analysis was performed using Chi-squared for categorical variables and t-test for continuous variables with age-, gender-, and race-adjusted odds ratios and their 95% confidence intervals (CIs) between HbA1c and diabetes with the presence of colonic adenomas were estimated using unconditional logistic regression model. SAS version 9.3 software was used to perform all statistical analysis. Results: When looking at combined data of both diagnostic and screening colonoscopies no association could be found between diabetes and the presence of colorectal adenoma over those without diabetes. When looking by level of controlled diabetes with a level below 6.5 vs 6.5-7.5 vs over 7.5 no association could be found between either the presence, size, location or number of adenomas. However when looking at only screening colonoscopies there was an association found between Hba1c level greater than 7.5 and the the presence of colorectal adenomas 2.16 (1.15,4.05). Conclusion: We found HbA1c >7.5 values were positively associated with colorectal adenoma presence, size, location, and number when looking at screening colonoscopies.