Abstract
During the past 10 years we have screened by electrophoresis 126,000 subjects from Northern Calabria for hemoglobinopathies, and identified 36 subjects belonging to 24 unrelated families as carriers of a hemoglobin (Hb) with a mobility slower than Hb A. Structural analysis has identified it as Hb D-Iran [β22(B4)Glu→ Gln], which was first described in 1973 (1). However, as early as in 1959 one of us discovered an abnormal Hb in Italy, which was electrophoretically identified as Hb D but was not specifically characterized (2).
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