HAuCl4 Catalyzed and Dibenzyl amine Centered A3 coupling reaction: Synthesis, Spectroscopic Proofing and Anti‐microbial Efficacy

Abstract

AbstractThis research suggests an ideal method for synthesizing propargyl amine adducts by a three‐component condensation of dibenzyl amine (DBA), aldehyde, and phenylacetylene (known as A3 coupling reactions). The aimed synthesis was carried out using a gold catalyst, chlouro auric acid (HAuCl4) and compared with Cu(I) systems to check the involvement of metals to generate enantiomerically pure compounds (4 a–4 j). No major deactivation of the catalyst was observed after repeated use in a similar reaction system (>10 times). The derived motifs′ spectroscopic profiling (1H NMR, 13C NMR, APT, IR and MS) has confirmed the structural fragments in a single core. Moreover, the applications of the derived motifs confirmed the comparable antimicrobial activity in some selected Gram‐positive and Gram‐negative bacterial; and fungi strains. Our consequences show that the scaffolds 4 d and 4 i having 4‐F and 4‐NMe2 substitution in the araldehyde system exhibited potent antimicrobial activity in most used bacterial and fungi strains.