Abstract
Neurotrophic factors (NF) promote the survival of specific neuronal populations. BDNF and GNF have physiological effects on neurons such as inducing morphological differentiation, enhancing nerve regeneration, stimulating neurotransmitter expression, and otherwise altering the physiological characteristics of neurons. These properties suggest that NF are highly involved in pathologies of the peripheral nervous system. Hereditary transthyretin amyloidosis (hATTR) is a life‐threatening disease transmitted as an autosomal dominant trait with phenotypic variability expression among patients. Recently, we characterize a differential miRNA cluster circulating in plasma of hATTR patients. In order to investigate how these microRNAs can modify the epigenetic of nerve tissues, we transfected a Schwann cell line with let7 to show the functional proteomic manifestations. Changes of BDNF and NGF expression patterns were studied using qPCR, Western blot analysis, ELISA and immunohistochemistry. Our preliminary data showed a down expression of BDNF and NGF in this cells after transfection. This suggest that Let7 could be involved in the pathogenesis and progression of hATTR.
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