Hashimoto's Encephalopathy Presenting with Status Epilepticus and Mental Disorder as the Main Manifestations.

Abstract

Hashimotos encephalopathy (HE) is an uncommon disease. It is easily misdiagnosed as many clinicians have an insufficient understanding of it. The clinical presentation, auxiliary examination, diagnosis, and treatment of a patient with HE were retrospectively analysed, and the relevant literature was reviewed and summarised. The patient, a middle-aged woman, presented with status epilepticus, persecutive delusions, elevated serum thyroid antibodies, and a negative autoantibody profile test for autoimmune encephalitis and responded well to steroid pulse therapy and plasma exchange. Elevated serum thyroid antibodies are the most important investigations for the diagnosis of HE. Most patients have a good prognosis but early investigation of thyroid function and antibodies is imperative for an early and accurate diagnosis. An early treatment can greatly improve patient prognosis. Key Words: Status epilepticus, Hashimotos encephalopathy, Autoimmune disease, Mental disorder.